How Does Lupus Affect Bone Density? Lupus can lead to decreased bone density, a condition known as osteoporosis. Chronic inflammation, the use of certain medications like corticosteroids, and reduced physical activity due to lupus-related symptoms can contribute to bone loss. Additionally, hormonal changes and vitamin D deficiency associated with lupus can further exacerbate the risk… Continue reading Core Connection: Bone Density and Lupus